The answer is $\boxed{65}$.
In the sequence $25:37$, the second number is $12$ more than the first number. In the sequence $49:?$, the second number is also $12$ more than the first number. Therefore, the answer is $49+12=\boxed{65}$.
Option A, $41$, is incorrect because it is not $12$ more than $49$. Option B, $65$, is correct because it is $12$ more than $49$. Option C, $56$, is incorrect because it is not $12$ more than $49$. Option D, $60$, is incorrect because it is not $12$ more than $49$.
