The spontaneity of a chemical reaction or physical process is primarily determined by the change in Gibbs Free Energy (∆G). The relationship is defined by the equation: ∆G = ∆H - T∆S, where ∆H is the change in enthalpy, T is the absolute temperature, and ∆S is the change in entropy. - If ∆G 0, the process is non-spontaneous under constant temperature and pressure (the reverse process is spontaneous). - If ∆G = 0, the system is at equilibrium.