Modern refrigerators use refrigerants like hydrofluorocarbons (HFCs), hydrocarbons (like isobutane and propane), ammonia, or carbon dioxide. These substances have a negligible or zero Ozone Depletion Potential (ODP), unlike the chlorofluorocarbons (CFCs) and hydrochlorofluorocarbons (HCFCs) used in older refrigeration systems.