The correct answer is B. Nickers.
A. Nuptial is a word that means relating to marriage. It is spelled correctly.
B. Nickers is a word that is not in the dictionary. It is likely a misspelling of the word "nickers," which is a type of underwear.
C. Nephew is a word that means the son of one's brother or sister. It is spelled correctly.
D. Nuisance is a word that means a person or thing that is annoying or troublesome. It is spelled correctly.