The missing number is 8.
The numbers in the sequence are all multiples of 4, starting with 4. The next number in the sequence is 8, which is 4 more than the previous number.
A. 4 is not the missing number because it is not a multiple of 4. B. 6 is not the missing number because it is not a multiple of 4. C. 8 is the missing number because it is a multiple of 4 and it is 4 more than the previous number. D. 12 is not the missing number because it is not a multiple of 4.