- Statement 1: Mitochondrial Replacement Therapy (MRT), including Pronuclear Transfer or Maternal Spindle Transfer techniques, aims to prevent the transmission of mitochondrial diseases from mother to child. These procedures involve transferring the nucleus from the affected mother's egg (or zygote) into a donor egg (or zygote) that has had its nucleus removed but retains healthy mitochondria. This can be performed either before or after fertilization (in vitro fertilization). - Statement 2: Mitochondria, organelles responsible for energy production within cells, contain their own DNA (mtDNA). In humans, mtDNA is almost exclusively inherited from the mother because the egg contributes the vast majority of cytoplasm (containing mitochondria) to the zygote, while the sperm contributes primarily nuclear DNA. Therefore, mitochondrial diseases are maternally inherited.