When muscles undergo intense activity with insufficient oxygen supply (anaerobic respiration), glucose is broken down into pyruvate, which is then converted into lactic acid. The build-up of lactic acid in muscle tissue lowers pH and interferes with muscle contraction mechanisms, leading to a burning sensation and fatigue.
Muscle fatigue is due to the accumulation of:
Asked in UPSC NDA 2 2015 · Topic: Skeletal and Muscle System (Muscle Physiology: Contraction Dynamics, Fatigue, and Fiber Types)
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