Osteoclasts are large multinucleated cells responsible for bone resorption, the process by which bone tissue is broken down. This process is essential for bone remodeling, which occurs continuously throughout life. Bone remodeling is crucial for maintaining bone health, adapting to stress, and repairing damage. While osteoclasts do not cause bone fractures, their activity is fundamental to the healing process following a fracture, where they clear damaged bone matrix before osteoblasts can lay down new bone. Therefore, osteoclasts are directly associated with the biological response to bone fracture for repair.