This question likely contains an inaccurate percentage figure (80%). Water is the substance that makes up the largest percentage of living material (typically 60-80%). Among the given options which represent organic macromolecules or minerals, protein is generally the most abundant component of living organisms by dry weight, and a significant component by wet weight (e.g., around 15-20% of human body mass). Given the options and the common biological composition, Protein is the most plausible answer despite the likely error in the 80% figure.