- Traits with low heritability MAS is particularly useful for traits with low heritability because traditional selection based on phenotype is less effective. Markers provide a more direct measure of the genetic potential. - Seedling stage MAS can be performed on DNA extracted from very young plants (seedlings), allowing for early selection and saving resources. - Desirable and undesirable genes MAS can be used to select for or against specific genes, regardless of whether they are considered "desirable" or "undesirable" in a particular context. - Pyramiding genes MAS is highly effective for pyramiding multiple genes into a single desirable genotype, which is crucial for developing traits like disease resistance or stress tolerance.