- Respiration (breathing) is driven by pressure differences between the lungs and the atmosphere. - Inspiration occurs when intrapulmonary pressure is lower than atmospheric pressure (diaphragm contracts, thoracic cavity expands). - Expiration occurs when intrapulmonary pressure is higher than atmospheric pressure (diaphragm relaxes, thoracic cavity volume decreases). - The diaphragm contracts during inspiration, not expiration (except forced expiration).