In the liver, methanol is oxidized by the enzyme alcohol dehydrogenase primarily into formaldehyde, which is also known as methanal. Formaldehyde is a potent toxin that can damage tissues, including causing the denaturation and coagulation of proteins, which is akin to coagulating protoplasm. Formaldehyde is further oxidized to formic acid, which contributes to metabolic acidosis.
Methanol is toxic because
Asked in UPSC CDS 1 2024 · Topic: Human Anatomy and Physiology (Digestive System)
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Answer: B. methanol gets oxidised to methanal in liver which coagulates the protoplasm
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