The atomic number of Helium (He) is 2, meaning it has 2 protons in its nucleus. The most abundant isotope of Helium is Helium-4 (^4He), which has a mass number of 4. The mass number is the sum of protons and neutrons. Therefore, for ^4He, Number of neutrons = Mass number - Number of protons = 4 - 2 = 2 neutrons.