The sensation of fatigue in the muscles after prolonged strenuous physical work is caused by:

Asked in HPPSC HPAS Prelims 2014 · UPPCS Prelims 2000 · Topic: Skeletal and Muscle System (Muscle Physiology: Contraction Dynamics, Fatigue, and Fiber Types)

1. a decrease in the supply of oxygen
2. minor wear and tear of muscles fibres
3. the depletion of glucose
4. the accumulation of lactic acid

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